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|00000480| 00 00 00 00 24 55 6e 69 | 71 75 65 5f 49 44 7b 59 |....$Uni|que_ID{Y|
|00000490| 52 42 31 32 31 30 30 7d | 0d 0a 24 54 69 74 6c 65 |RB12100}|..$Title|
|000004a0| 7b 43 68 61 72 61 63 74 | 65 72 69 7a 61 74 69 6f |{Charact|erizatio|
|000004b0| 6e 20 6f 66 20 46 72 65 | 71 75 65 6e 74 20 44 65 |n of Fre|quent De|
|000004c0| 6c 65 74 69 6f 6e 73 20 | 43 61 75 73 69 6e 67 20 |letions |Causing |
|000004d0| 53 74 65 72 6f 69 64 20 | 32 31 2d 48 79 64 72 6f |Steroid |21-Hydro|
|000004e0| 78 79 6c 61 73 65 20 44 | 65 66 69 63 69 65 6e 63 |xylase D|eficienc|
|000004f0| 79 7d 0d 0a 24 41 75 74 | 68 6f 72 7b 57 68 69 74 |y}..$Aut|hor{Whit|
|00000500| 65 2c 20 50 43 0d 0a 56 | 69 74 65 6b 2c 20 41 0d |e, PC..V|itek, A.|
|00000510| 0a 44 75 70 6f 6e 74 2c | 20 42 0d 0a 4e 65 77 2c |.Dupont,| B..New,|
|00000520| 20 4d 49 7d 0d 0a 24 41 | 66 66 69 6c 69 61 74 69 | MI}..$A|ffiliati|
|00000530| 6f 6e 7b 43 6f 72 6e 65 | 6c 6c 20 55 6e 69 76 3b |on{Corne|ll Univ;|
|00000540| 20 53 6c 6f 61 6e 2d 4b | 65 74 74 65 72 69 6e 67 | Sloan-K|ettering|
|00000550| 20 49 6e 73 74 2c 20 4e | 65 77 20 59 6f 72 6b 7d | Inst, N|ew York}|
|00000560| 0d 0a 24 4a 6f 75 72 6e | 61 6c 7b 50 72 6f 63 20 |..$Journ|al{Proc |
|00000570| 4e 61 74 6c 20 41 63 61 | 64 20 53 63 69 20 55 53 |Natl Aca|d Sci US|
|00000580| 41 7d 0d 0a 24 56 6f 6c | 75 6d 65 7b 38 33 7d 0d |A}..$Vol|ume{83}.|
|00000590| 0a 24 50 61 67 65 7b 34 | 34 33 36 2d 34 34 34 30 |.$Page{4|436-4440|
|000005a0| 7d 0d 0a 24 44 61 74 65 | 7b 4a 75 6e 65 20 31 39 |}..$Date|{June 19|
|000005b0| 38 38 7d 0d 0a 24 59 42 | 56 6f 6c 7b 31 39 39 30 |88}..$YB|Vol{1990|
|000005c0| 20 59 65 61 72 20 42 6f | 6f 6b 20 6f 66 20 50 65 | Year Bo|ok of Pe|
|000005d0| 64 69 61 74 72 69 63 73 | 7d 0d 0a 24 43 68 61 70 |diatrics|}..$Chap|
|000005e0| 74 65 72 7b 31 37 2d 31 | 31 7d 0d 0a 24 59 42 45 |ter{17-1|1}..$YBE|
|000005f0| 64 69 74 6f 72 7b 44 72 | 73 2e 20 4f 73 6b 69 20 |ditor{Dr|s. Oski |
|00000600| 61 6e 64 20 53 74 6f 63 | 6b 6d 61 6e 7d 0d 0a 24 |and Stoc|kman}..$|
|00000610| 54 61 62 6c 65 7b 7d 0d | 0a 24 43 6f 6d 6d 65 6e |Table{}.|.$Commen|
|00000620| 74 61 74 6f 72 7b 4a 2e | 41 2e 20 53 74 6f 63 6b |tator{J.|A. Stock|
|00000630| 6d 61 6e 2c 20 49 49 49 | 2c 20 4d 2e 44 2e 7d 0d |man, III|, M.D.}.|
|00000640| 0a 0d 0a 43 6f 70 79 72 | 69 67 68 74 20 28 63 29 |...Copyr|ight (c)|
|00000650| 20 59 65 61 72 62 6f 6f | 6b 20 4d 65 64 69 63 61 | Yearboo|k Medica|
|00000660| 6c 20 50 75 62 6c 69 73 | 68 65 72 73 2c 20 49 6e |l Publis|hers, In|
|00000670| 63 2e 2c 20 31 39 39 30 | 0d 0a 0d 0a 31 39 39 30 |c., 1990|....1990|
|00000680| 20 59 65 61 72 20 42 6f | 6f 6b 20 6f 66 20 50 65 | Year Bo|ok of Pe|
|00000690| 64 69 61 74 72 69 63 73 | 20 28 52 29 0d 0a 0d 0a |diatrics| (R)....|
|000006a0| 43 68 61 70 74 65 72 20 | 31 37 2d 2d 45 6e 64 6f |Chapter |17--Endo|
|000006b0| 63 72 69 6e 6f 6c 6f 67 | 79 0d 0a 0d 0a 2d 2d 2d |crinolog|y....---|
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|00000710| 72 61 63 74 65 72 69 7a | 61 74 69 6f 6e 20 6f 66 |racteriz|ation of|
|00000720| 20 46 72 65 71 75 65 6e | 74 20 44 65 6c 65 74 69 | Frequen|t Deleti|
|00000730| 6f 6e 73 20 43 61 75 73 | 69 6e 67 20 53 74 65 72 |ons Caus|ing Ster|
|00000740| 6f 69 64 20 32 31 2d 48 | 79 64 72 6f 78 79 6c 61 |oid 21-H|ydroxyla|
|00000750| 73 65 0d 0a 44 65 66 69 | 63 69 65 6e 63 79 0d 0a |se..Defi|ciency..|
|00000760| 0d 0a 57 68 69 74 65 20 | 50 43 2c 20 56 69 74 65 |..White |PC, Vite|
|00000770| 6b 20 41 2c 20 44 75 70 | 6f 6e 74 20 42 2c 20 4e |k A, Dup|ont B, N|
|00000780| 65 77 20 4d 49 0d 0a 28 | 43 6f 72 6e 65 6c 6c 20 |ew MI..(|Cornell |
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|000007a0| 65 72 69 6e 67 20 49 6e | 73 74 2c 20 4e 65 77 20 |ering In|st, New |
|000007b0| 59 6f 72 6b 29 0d 0a 50 | 72 6f 63 20 4e 61 74 6c |York)..P|roc Natl|
|000007c0| 20 41 63 61 64 20 53 63 | 69 20 55 53 41 20 38 33 | Acad Sc|i USA 83|
|000007d0| 3a 34 34 33 36 2d 34 34 | 34 30 2c 20 4a 75 6e 65 |:4436-44|40, June|
|000007e0| 20 31 39 38 38 0d 0a 2d | 2d 2d 2d 2d 2d 2d 2d 2d | 1988..-|--------|
|000007f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00000830| 2d 2d 2d 2d 2d 0d 0a 0d | 0a 41 62 73 74 72 61 63 |-----...|.Abstrac|
|00000840| 74 0d 0a 0d 0a 20 20 20 | 20 20 53 74 65 72 6f 69 |t....   |  Steroi|
|00000850| 64 20 32 31 2d 68 79 64 | 72 6f 78 79 6c 61 73 65 |d 21-hyd|roxylase|
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|00000930| 6f 6d 65 20 50 34 35 30 | 20 65 6e 7a 79 6d 65 20 |ome P450| enzyme |
|00000940| 74 68 61 74 20 68 79 64 | 72 6f 78 79 6c 61 74 65 |that hyd|roxylate|
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|00005150| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005160| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005170| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 0d 0a 0d 0a |--------|----....|
|00005180| 41 62 73 74 72 61 63 74 | 0d 0a 0d 0a 20 20 20 20 |Abstract|....    |
|00005190| 20 54 6f 65 20 74 72 61 | 6e 73 66 65 72 20 69 73 | Toe tra|nsfer is|
|000051a0| 20 61 20 63 6f 6d 6d 6f | 6e 20 70 72 6f 63 65 64 | a commo|n proced|
|000051b0| 75 72 65 20 66 6f 72 20 | 72 65 70 6c 61 63 69 6e |ure for |replacin|
|000051c0| 67 20 74 68 75 6d 62 73 | 20 6c 6f 73 74 20 74 68 |g thumbs| lost th|
|000051d0| 72 6f 75 67 68 0d 0a 74 | 72 61 75 6d 61 3b 20 68 |rough..t|rauma; h|
|000051e0| 6f 77 65 76 65 72 2c 20 | 69 74 20 69 73 20 62 65 |owever, |it is be|
|000051f0| 6c 69 65 76 65 64 20 74 | 6f 20 62 65 20 75 6e 73 |lieved t|o be uns|
|00005200| 75 63 63 65 73 73 66 75 | 6c 20 69 6e 20 73 75 62 |uccessfu|l in sub|
|00005210| 73 74 69 74 75 74 69 6e | 67 20 66 6f 72 0d 0a 63 |stitutin|g for..c|
|00005220| 6f 6e 67 65 6e 69 74 61 | 6c 6c 79 20 61 62 73 65 |ongenita|lly abse|
|00005230| 6e 74 20 74 68 75 6d 62 | 73 2e 20 20 54 77 65 6c |nt thumb|s.  Twel|
|00005240| 76 65 20 73 75 63 68 20 | 74 72 61 6e 73 66 65 72 |ve such |transfer|
|00005250| 73 20 77 65 72 65 20 70 | 65 72 66 6f 72 6d 65 64 |s were p|erformed|
|00005260| 20 69 6e 20 63 68 69 6c | 64 72 65 6e 0d 0a 61 67 | in chil|dren..ag|
|00005270| 65 64 20 31 2d 38 20 79 | 65 61 72 73 20 77 68 6f |ed 1-8 y|ears who|
|00005280| 20 77 65 72 65 20 63 6f | 6e 67 65 6e 69 74 61 6c | were co|ngenital|
|00005290| 6c 79 20 64 65 66 69 63 | 69 65 6e 74 20 62 65 63 |ly defic|ient bec|
|000052a0| 61 75 73 65 20 6f 66 20 | 74 72 61 6e 73 76 65 72 |ause of |transver|
|000052b0| 73 65 20 61 72 72 65 73 | 74 2c 0d 0a 63 6f 6e 73 |se arres|t,..cons|
|000052c0| 74 72 75 63 74 69 6f 6e | 20 72 69 6e 67 20 73 79 |truction| ring sy|
|000052d0| 6e 64 72 6f 6d 65 2c 20 | 6f 72 20 73 79 6d 62 72 |ndrome, |or symbr|
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|00005310| 79 20 64 65 73 63 72 69 | 62 65 64 2c 20 72 65 71 |y descri|bed, req|
|00005320| 75 69 72 65 64 20 6d 6f | 64 69 66 69 63 61 74 69 |uired mo|dificati|
|00005330| 6f 6e 73 20 74 6f 20 61 | 63 63 6f 6d 6d 6f 64 61 |ons to a|ccommoda|
|00005340| 74 65 20 61 6e 61 74 6f | 6d 69 63 61 6c 0d 0a 76 |te anato|mical..v|
|00005350| 61 72 69 61 74 69 6f 6e | 73 20 73 6f 20 74 68 61 |ariation|s so tha|
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|00005390| 6f 6e 6e 65 63 74 65 64 | 20 74 6f 0d 0a 76 61 72 |onnected| to..var|
|000053a0| 69 6f 75 73 20 61 76 61 | 69 6c 61 62 6c 65 20 73 |ious ava|ilable s|
|000053b0| 74 72 75 63 74 75 72 65 | 73 2e 0d 0a 20 20 20 20 |tructure|s...    |
|000053c0| 20 41 6c 6c 20 31 32 20 | 74 6f 65 20 74 72 61 6e | All 12 |toe tran|
|000053d0| 73 66 65 72 73 20 73 75 | 72 76 69 76 65 64 2c 20 |sfers su|rvived, |
|000053e0| 77 69 74 68 20 6f 6e 6c | 79 20 31 20 70 61 74 69 |with onl|y 1 pati|
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|00005400| 70 6c 6f 72 61 74 69 6f | 6e 0d 0a 61 6e 64 20 31 |ploratio|n..and 1|
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|000054a0| 74 69 65 6e 74 73 20 6d | 61 64 65 20 67 6f 6f 64 |tients m|ade good|
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|000054d0| 65 6e 73 61 74 69 6f 6e | 2c 20 62 75 74 0d 0a 69 |ensation|, but..i|
|000054e0| 6e 74 65 72 70 68 61 6c | 61 6e 67 65 61 6c 20 6d |nterphal|angeal m|
|000054f0| 6f 74 69 6f 6e 20 77 61 | 73 20 61 63 68 69 65 76 |otion wa|s achiev|
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|00005520| 73 65 20 72 65 73 75 6c | 74 73 20 73 75 67 67 65 |se resul|ts sugge|
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|00005540| 73 66 65 72 20 63 61 6e | 20 62 65 20 75 6e 64 65 |sfer can| be unde|
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|00005560| 72 65 6d 65 64 79 0d 0a | 63 6f 6e 67 65 6e 69 74 |remedy..|congenit|
|00005570| 61 6c 20 64 65 66 69 63 | 69 65 6e 63 79 20 6f 66 |al defic|iency of|
|00005580| 20 74 68 65 20 74 68 75 | 6d 62 2e 20 20 4e 6f 20 | the thu|mb.  No |
|00005590| 70 61 72 74 69 63 75 6c | 61 72 20 70 72 6f 62 6c |particul|ar probl|
|000055a0| 65 6d 73 20 61 70 70 65 | 61 72 20 74 6f 20 62 65 |ems appe|ar to be|
|000055b0| 0d 0a 61 73 73 6f 63 69 | 61 74 65 64 20 77 69 74 |..associ|ated wit|
|000055c0| 68 20 74 68 65 20 75 73 | 65 20 6f 66 20 74 68 69 |h the us|e of thi|
|000055d0| 73 20 6d 69 63 72 6f 73 | 75 72 67 69 63 61 6c 20 |s micros|urgical |
|000055e0| 74 65 63 68 6e 69 71 75 | 65 20 69 6e 20 69 6e 66 |techniqu|e in inf|
|000055f0| 61 6e 74 73 20 61 6e 64 | 2c 0d 0a 61 6c 74 68 6f |ants and|,..altho|
|00005600| 75 67 68 20 69 6e 74 65 | 72 70 68 61 72 79 6e 67 |ugh inte|rpharyng|
|00005610| 65 61 6c 20 6d 6f 74 69 | 6f 6e 20 77 61 73 20 6f |eal moti|on was o|
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|00005650| 74 6f 20 66 6f 6c 6c 6f | 77 2d 75 70 20 75 73 65 |to follo|w-up use|
|00005660| 20 74 68 65 20 64 69 67 | 69 74 20 74 6f 20 67 6f | the dig|it to go|
|00005670| 6f 64 20 65 66 66 65 63 | 74 2e 0d 0a 0d 0a 50 6f |od effec|t.....Po|
|00005680| 73 74 2d 43 6f 6d 6d 65 | 6e 74 0d 0a 0d 0a 20 20 |st-Comme|nt....  |
|00005690| 20 20 20 57 68 61 74 20 | 70 6c 61 73 74 69 63 20 |   What |plastic |
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|00005710| 22 54 68 61 74 27 73 20 | 49 6e 63 72 65 64 69 62 |"That's |Incredib|
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|00005750| 4a 6f 68 6e 20 44 61 76 | 69 64 73 6f 6e 20 61 6e |John Dav|idson an|
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|000057b0| 2d 4a 2e 41 2e 20 53 74 | 6f 63 6b 6d 61 6e 2c 0d |-J.A. St|ockman,.|
|000057c0| 0a 49 49 49 2c 20 4d 2e | 44 2e 0d 0a 24 55 6e 69 |.III, M.|D...$Uni|
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|00005830| 61 67 6e 6f 73 69 73 20 | 6f 66 20 4c 6f 77 2d 42 |agnosis |of Low-B|
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|00005860| 74 68 6f 72 7b 42 6f 64 | 6e 65 72 2c 20 52 4a 0d |thor{Bod|ner, RJ.|
|00005870| 0a 48 65 79 6d 61 6e 2c | 20 53 0d 0a 44 72 75 6d |.Heyman,| S..Drum|
|00005880| 6d 6f 6e 64 2c 20 44 53 | 0d 0a 47 72 65 67 67 2c |mond, DS|..Gregg,|
|00005890| 20 4a 52 7d 0d 0a 24 41 | 66 66 69 6c 69 61 74 69 | JR}..$A|ffiliati|
|000058a0| 6f 6e 7b 43 68 69 6c 64 | 72 65 6e 27 73 20 48 6f |on{Child|ren's Ho|
|000058b0| 73 70 20 6f 66 20 50 68 | 69 6c 61 64 65 6c 70 68 |sp of Ph|iladelph|
|000058c0| 69 61 7d 0d 0a 24 4a 6f | 75 72 6e 61 6c 7b 53 70 |ia}..$Jo|urnal{Sp|
|000058d0| 69 6e 65 7d 0d 0a 24 56 | 6f 6c 75 6d 65 7b 31 33 |ine}..$V|olume{13|
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|000058f0| 36 30 7d 0d 0a 24 44 61 | 74 65 7b 4f 63 74 6f 62 |60}..$Da|te{Octob|
|00005900| 65 72 20 31 39 38 38 7d | 0d 0a 24 59 42 56 6f 6c |er 1988}|..$YBVol|
|00005910| 7b 31 39 39 30 20 59 65 | 61 72 20 42 6f 6f 6b 20 |{1990 Ye|ar Book |
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|00005940| 24 59 42 45 64 69 74 6f | 72 7b 44 72 73 2e 20 4f |$YBEdito|r{Drs. O|
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|00005980| 74 6f 63 6b 6d 61 6e 2c | 20 49 49 49 2c 20 4d 2e |tockman,| III, M.|
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|000059f0| 0d 0a 0d 0a 43 68 61 70 | 74 65 72 20 31 38 2d 2d |....Chap|ter 18--|
|00005a00| 54 68 65 20 4d 75 73 63 | 75 6c 6f 73 6b 65 6c 65 |The Musc|uloskele|
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|00005a50| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005a60| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 0d 0a 54 68 |--------|----..Th|
|00005a70| 65 20 55 73 65 20 6f 66 | 20 53 69 6e 67 6c 65 20 |e Use of| Single |
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|00005ac0| 20 4c 6f 77 2d 42 61 63 | 6b 20 50 61 69 6e 20 69 | Low-Bac|k Pain i|
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|00005ae0| 0d 0a 0d 0a 42 6f 64 6e | 65 72 20 52 4a 2c 20 48 |....Bodn|er RJ, H|
|00005af0| 65 79 6d 61 6e 20 53 2c | 20 44 72 75 6d 6d 6f 6e |eyman S,| Drummon|
|00005b00| 64 20 44 53 2c 20 47 72 | 65 67 67 20 4a 52 0d 0a |d DS, Gr|egg JR..|
|00005b10| 28 43 68 69 6c 64 72 65 | 6e 27 73 20 48 6f 73 70 |(Childre|n's Hosp|
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|00005b30| 29 0d 0a 53 70 69 6e 65 | 20 31 33 3a 31 31 35 35 |)..Spine| 13:1155|
|00005b40| 2d 31 31 36 30 2c 20 4f | 63 74 6f 62 65 72 20 31 |-1160, O|ctober 1|
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|00005ba0| 2d 2d 2d 0d 0a 0d 0a 41 | 62 73 74 72 61 63 74 0d |---....A|bstract.|
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|00005c80| 20 20 41 20 73 74 75 64 | 79 20 77 61 73 20 63 6f |  A stud|y was co|
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|00005d70| 20 70 61 74 69 65 6e 74 | 73 0d 0a 61 67 65 64 20 | patient|s..aged |
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|00005e70| 65 73 2c 20 70 6c 61 6e | 61 72 20 62 6f 6e 65 20 |es, plan|ar bone |
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+--------+-------------------------+-------------------------+--------+--------+